Cyclo(-Pro-Val)

Names

[ Name ]:
Cyclo(-Pro-Val)

[Synonym ]:
Cyclo(-Pro-Val)
cyclo-(L-Val-L-Pro)
cyclo(-L-pro-L-val-)
(3S,8aS)-3-Isopropylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Biological Activity

[Description]:

Cyclo(L-Pro-L-Val) is a 2,5-diketopiperazine, with toxic activity against phytopathogenic microorganisms (such as R. fascians LMG 3605). Cyclo(L-Pro-L-Val) shows toxicity similar to Chloramphenicol (HY-B0239) with comparable concentration. Cyclo(L-Pro-L-Val) can also inhibit gram-positive phytopathogenic bacterium. Cyclo(L-Pro-L-Val) has potential development as biopesticide[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Cimmino A, et al. Isolation of 2,5-diketopiperazines from Lysobacter capsici AZ78 with activity against Rhodococcus fascians. Nat Prod Res. 2021 Dec;35(23):4969-4977.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₆N₂O₂

[ Molecular Weight ]:
196.25

[ Exact Mass ]:
196.12100

[ PSA ]:
49.41000

[ LogP ]:
0.39850

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%