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S 14506 hydrochloride

Names

[ CAS No. ]:
286369-38-8

[ Name ]:
S 14506 hydrochloride

[Synonym ]:
S-14506 HYDROCHLORIDE
4-Fluoro-N-{2-[4-(7-methoxy-1-naphthyl)-1-piperazinyl]ethyl}benzamide hydrochloride (1:1)
MFCD00910294
Benzamide, 4-fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]-, hydrochloride (1:1)
4-Fluoro-N-{2-[4-(7-methoxy-1-naphthyl)piperazin-1-yl]ethyl}benzamide hydrochloride (1:1)
4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide hydrochloride

Biological Activity

[Description]:

S-14506 hydrochloride is a potent 5-HT1A agonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent[1][2].

[Related Catalog]:

Research Areas >> Others
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Francis C. Colpaert, et al. S 14506: A novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent. 1992, 21-48.

[2]. Protais P, et al. Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents. Eur J Pharmacol. 1994 Dec 12;271(1):167-77.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H27ClFN3O2

[ Molecular Weight ]:
443.941

[ Exact Mass ]:
443.177582

Related Compounds