GBD-9

Names

[ CAS No. ]:
2864408-92-2

[ Name ]:
GBD-9

Biological Activity

[Description]:

GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. GBD-9 effectively inhibits cancer cell growth[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
Signaling Pathways >> PROTAC >> PROTAC

[Target]

Cereblon


[References]

[1]. Zimo Yang, et al. Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently. Cell Res. 2021 Dec;31(12):1315-1318.  

Chemical & Physical Properties

[ Molecular Formula ]:
C44H47N9O6

[ Molecular Weight ]:
797.90

Related Compounds