STING agonist-26

Names

[ CAS No. ]:
2868261-48-5

[ Name ]:
STING agonist-26

Biological Activity

[Description]:

STING agonist-26 (CF508) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Immunology/Inflammation >> STING

[In Vitro]

STING agonist-26 (10 μM；3 小时或 5 小时) 处理 THP-1 细胞 3 小时后，增加磷酸化 STING、TBK1 和 IRF3 的水平；处理 THP-1 细胞 5 小时后，增加 IFN-β、IL-6、CXCL-10、TNF-α、ISG-15 和 CCL-5 的含量[1]。

[In Vivo]

STING agonist-26 佐剂 (20μg STING agonist-26+5μg RBD-Fc/小鼠；肌肉注射；每 14 天间隔 3 次) 在小鼠模型中增强由 SARS-CoV-2 RBD-Fc 蛋白诱导的强烈抗体免疫反应[1]。

[References]

[1]. Liu Z, et al. A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs. Cell Res. 2022 Mar;32(3):269-287.  

Chemical & Physical Properties

[ Molecular Formula ]:
C40H49N15O5

[ Molecular Weight ]:
819.91

Related Compounds