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Y-320

Names

[ CAS No. ]:
288250-47-5

[ Name ]:
Y-320

[Synonym ]:
1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-
1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl}-5-methyl-1H-pyrazole-4-carboxamide
1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide
Y320
Y-320

Biological Activity

[Description]:

Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.IC50 value: 20-60 nM (IL-17 production) [1]Target: IL-17Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral administration of Y-320 (0.3 to 3 mg/kg) significantly inhibited the development and progression of arthritis and joint destruction with reduction of IL-17 mRNA expression in arthritic joints of type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 in combination with anti-murine tumor necrosis factor-α monoclonal antibody showed a synergistic effect on mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys [1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Research Areas >> Inflammation/Immunology

[References]

[1]. Ushio H, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17.


[Related Small Molecules]

DMXAA (Vadimezan) | apilimod | SC144 | APY0201 | Vidofludimus | Diacerein | AX-024 hydrochloride | Ginsenoside Rh1 | BAY 2402234 | Neochlorogenic acid | GIBH-130 | Ginsenoside Rc | Mulberroside A | Suplatast Tosilate | Cineole

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
631.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H29ClN6O2

[ Molecular Weight ]:
505.011

[ Flash Point ]:
335.6±31.5 °C

[ Exact Mass ]:
504.204041

[ PSA ]:
86.42000

[ LogP ]:
3.58

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.675

[ Storage condition ]:
-20℃

Related Compounds