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Oxi 4503

Names

[ CAS No. ]:
288847-35-8

[ Name ]:
Oxi 4503

[Synonym ]:
CA1P
OXI-4503
UNII-JH6Z94GLUD
1,2-Benzenediol,3-methoxy-6-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-,1,2-bis(dihydrogen phosphate)
Combretastatin A-1 bis(phosphate)
Oxi 4503

Biological Activity

[Description]:

Combretastatin A1 phosphate (Oxi4503; CA1P; Combretastatin A1 diphosphate) is a potent vascular disruptive agent. Combretastatin A1 phosphate exerts anti-angiogenic effects on tumors. Combretastatin A1 phosphate has the potential for the research of pancreatic neuroendocrine tumors[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vivo]

Combretastatin A1 phosphate (100 mg/kg; I.p.; once at day 16 post tumor induction) 显示出抗肿瘤活性，并对小鼠肿瘤发挥抗血管生成作用当与 Sunitinib (HY-10255A) 连用时[2]。 Animal Model: Male CBA mice (CRC liver metastasis)[2] Dosage: 100 mg/kg (received 40 mg/kg of Sunitinib daily from day 14 to 21 post tumor induction) Administration: I.p.; once at day 16 post tumor induction Result: Demonstrated a significantly decreased mean liver weight compared to livers from non tumor bearing animals, significantly reduced tumor vessels.

[References]

[1]. Patterson DM, et al. Phase I clinical and pharmacokinetic evaluation of the vascular-disrupting agent OXi4503 in patients with advanced solid tumors. Clin Cancer Res. 2012 Mar 1;18(5):1415-25.  

[2]. Nguyen L, et al. Vascular disruptive agent OXi4503 and anti-angiogenic agent Sunitinib combination treatment prolong survival of mice with CRC liver metastasis. BMC Cancer. 2016 Jul 26;16:533.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H22O12P2

[ Molecular Weight ]:
492.30800

[ Exact Mass ]:
492.05900

[ PSA ]:
190.06000

[ LogP ]:
2.83440

Related Compounds