CB 300919

Names

[ Name ]:
CB 300919

[Synonym ]:
4-[N-[7-chloro-3-methyl-2-(4-methyl-piperazin-1-yl)methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(pyridin-3-ylmethyl)benzamide
CS-0523
UNII-55I8ETE76Y
4-[N-[7-chloro-3-methyl-2-(4-methyl-piperazin-1-yl)methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide
CB 300919

Biological Activity

[Description]:

CB 300919 is a water-soluble analogue of CB30865; has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft.IC50 value:Target: Nampt

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt

Research Areas >> Cancer

[References]

[1]. Lockman JW, et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt). J. Med. Chem., 2010, 53 (24), pp 8734-87

[2]. Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45(17), 3692-3702.

[Related Small Molecules]

FK866 (APO866, Daporinad) | P7C3 | STF 118804 | GMX1778 | KPT-9274 | GNE-617 | Nampt-IN-1 | CB30865

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₄ClN₇O₂

[ Molecular Weight ]:
584.11100

[ Exact Mass ]:
583.24600

[ PSA ]:
86.60000

[ LogP ]:
3.56580

[ Storage condition ]:
2-8℃

CB 300919

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds