2-Amino-2-deoxy-D-glucose sulfate (1:1)

Names

[ Name ]:
2-Amino-2-deoxy-D-glucose sulfate (1:1)

[Synonym ]:
D-Glucose, 2-amino-2-deoxy-, sulfate (1:1)
D-Glucosamine sulfate
2-Amino-2-deoxy-D-glucose sulfate (1:1)
EINECS 249-379-6
MFCD00151175

Biological Activity

[Description]:

Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

[Target]

Human Endogenous Metabolite

[In Vitro]

Glucosamine sulfate (D-Glucosamine sulfate) exhibits dose-dependent DPPH antioxidant activity[2]. Glucosamine sulfate treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins[3]. Glucosamine sulfate significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells[4].

[References]

[1]. Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S12-7.

[2]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9.

[3]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706.

[4]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84.

Chemical & Physical Properties

[ Density]:
1.563g/cm3

[ Boiling Point ]:
449.9ºC at 760mmHg

[ Melting Point ]:
176°C

[ Molecular Formula ]:
C₆H₁₃NO_5.xH₂O₄S

[ Molecular Weight ]:
277.250

[ Flash Point ]:
225.9ºC

[ Exact Mass ]:
277.046753

[ PSA ]:
206.99000

[ Vapour Pressure ]:
5.53E-10mmHg at 25°C

[ Storage condition ]:
-20?C Freezer

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

[ RTECS ]:
AU7417000

[ HS Code ]:
2932999099

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%