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Guanfacine

Names

[ CAS No. ]:
29110-47-2

[ Name ]:
Guanfacine

[Synonym ]:
Intuniv
Guanfacine
Guanfacina [INN-Spanish]
[(2,6-Dichlorophenyl)acetyl]guanidine
Guanfacine [INN:BAN]
Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-
N-amidino-2-(2,6-dichlorophenyl)acetamide
N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide
Estulic
Lon798
Guanfacina
N-(aminoiminomethyl)-2,6-dichlorobenzeneacetamide
Guanfacinum
Guanfacinum [INN-Latin]
BS 100-141
Tenex

Biological Activity

[Description]:

Guanfacine is a selective α2A receptor agonist.Target: α2A ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone [1, 2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Neurological Disease

[References]

[1]. Kolar, D., et al., Treatment of adults with attention-deficit/hyperactivity disorder. Neuropsychiatr Dis Treat, 2008. 4(2): p. 389-403.

[2]. Zwieten, P.v., M. Thoolen, and P. Timmermans, The pharmacology of centrally acting antihypertensive drugs. British journal of clinical pharmacology, 1983. 15(Supplement s4): p. 455S-462S.


[Related Small Molecules]

Isoprenaline hydrochloride | ICI 118,551 (hydrochloride) | Phenylephrine hydrochloride | Yohimbine hydrochloride | Adrenaline | Ivabradine hydrochloride | Prazosin hydrochloride | Clenbuterol hydrochloride | Phentolamine mesilate | guanfacine hydrochloride | pimozide | Sotalol hydrochloride | Carvedilol | Atenolol | Metroprolol succinate

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
424.9ºC at 760 mmHg

[ Melting Point ]:
227-230?C

[ Molecular Formula ]:
C9H9Cl2N3O

[ Molecular Weight ]:
246.093

[ Flash Point ]:
210.8ºC

[ Exact Mass ]:
245.012268

[ PSA ]:
78.97000

[ LogP ]:
1.12

[ Vapour Pressure ]:
2E-07mmHg at 25°C

[ Index of Refraction ]:
1.635

[ Storage condition ]:
Refrigerator

Safety Information

[ HS Code ]:
2925290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Related Compounds