Methylprednisolone succinate

Names

[ Name ]:
Methylprednisolone succinate

[Synonym ]:
Urbason-Soluble
methylprednisolone 21-hemisuccinate
Butanedioic acid, mono[(6α,11β)-11,17-dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl] ester
MFCD00271782
4-{[(6α,11β)-11,17-Dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl]oxy}-4-oxobutanoic acid
Methylprednisolone sodium hemisuccinate
6-methylprednisolone-21-hemisuccinate
methylprednisolone hemisuccinate esters
Methylprednisolone hydrogen succinate
Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, (6α,11β)-
Solumedrol
EINECS 220-863-9
UNII-5GMR90S4KN
METHYLPREDNISOLONE SODIUM SUCCINATE
11b,17,21-Trihydroxy-6a-methylpregna-1,4-diene-3,20-dione 21-(Hydrogen Succinate)
Methylprednisolone hemisuccinate
methylprednisolone succinate

Biological Activity

[Description]:

Methylprednisolone succinate is a synthetic glucocorticoid and widely used as an anti-inflammatory agent.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[Target]

glucocorticoid receptor[1]

[References]

[1]. Marchant A, et al. Methylprednisolone differentially regulates IL-10 and tumour necrosis factor (TNF) productionduring murine endotoxaemia. Clin Exp Immunol. 1996 Oct;106(1):91-6.

[2]. Diem R, et al. Methylprednisolone increases neuronal apoptosis during autoimmune CNS inflammation by inhibition of an endogenous neuroprotective pathway. J Neurosci. 2003 Aug 6;23(18):6993-7000.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
689.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₃₄O₈

[ Molecular Weight ]:
474.543

[ Flash Point ]:
230.7±25.0 °C

[ Exact Mass ]:
474.225372

[ PSA ]:
138.20000

[ LogP ]:
2.69

[ Vapour Pressure ]:
0.0±4.9 mmHg at 25°C

[ Index of Refraction ]:
1.593

[ Storage condition ]:
2-8℃

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2942000000

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