TRK-IN-23

Names

[ CAS No. ]:
2924344-29-4

[ Name ]:
TRK-IN-23

Biological Activity

[Description]:

TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKAG595R, TRKAF589L, and TRKAG667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor

[Target]

TrkA:0.5 nM (IC50)

TrkC:9 nM (IC50)

TRKAG595R:14 nM (IC50)

TRKAF589L:4.4 nM (IC50)

TRKAG667C:4.8 nM (IC50)


[References]

[1]. Qiaohua Qin, et al. Design, synthesis and biological evaluation of novel indolin-2-one derivatives as potent second-generation TRKs inhibitors. Eur J Med Chem. 2023 May 5;253:115291.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H17FN4O2

[ Molecular Weight ]:
364.37

Related Compounds