HIV-1 protease-IN-9

Names

[ Name ]:
HIV-1 protease-IN-9

Biological Activity

[Description]:

HIV-1 protease-IN-9 (compound 5b) is a HIV-1 protease inhibitor, with a Ki of 0.028 nM. HIV-1 protease-IN-9 shows potent antiviral activity, with an IC50 of 66.8 nM[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease

[References]

[1]. Ghosh AK, et, al. Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation. Eur J Med Chem. 2023 Jul 5;255:115385.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₇H₄₁N₇O₄S

[ Molecular Weight ]:
679.83