UNC8153 TFA

Names

[ Name ]:
UNC8153 TFA

Biological Activity

[Description]:

UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[References]

[1]. Ronan P Hanley, et al. Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. J Am Chem Soc. 2023 Apr 12;145(14):8176-8188.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₅H₃₈F₃N₅O₇

[ Molecular Weight ]:
697.70

UNC8153 TFA

Names

Biological Activity

Chemical & Physical Properties

Related Compounds