EGFR-IN-88

Names

[ CAS No. ]:
2944452-34-8

[ Name ]:
EGFR-IN-88

Biological Activity

[Description]:

EGFR-IN-88 (Compound 4i) is an EGFR inhibitor (IC50: 87 nM). EGFR-IN-88 shows cytotoxicity against A549 cell with an IC50? of 3.902? μM. EGFR-IN-88 can induce cell apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

87 nM (EGFR)[1]


[References]

[1]. Ali SH, et al. Design, synthesis, and molecular docking studies of novel quinoxaline derivatives as anticancer agents. Chem Biol Drug Des. 2023 Aug;102(2):303-315.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H18Cl2N4O2S

[ Molecular Weight ]:
473.37

Related Compounds