Negletein

Names

[ Name ]:
Negletein

[Synonym ]:
BAICALEIN-7-METHYL ETHER
7-O-Methylbaicalein
5,6-dihydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one
5,6-dihydroxy-7-methoxy-2-phenyl-4H-chromen-4-one
BAICALEIN METHYL ETHER
NEGLETEIN
5,6-dihydroxy-7-methoxy-2-phenyl-chromen-4-one

Biological Activity

[Description]:

Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 and 10.8 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[References]

[1]. Phan CW, et al. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Biofactors. 2016 Nov 12;42(6):591-599.

[2]. Singh B, et al. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.Nat Prod Res. 2013;27(23):2227-30.

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Boiling Point ]:
541.1ºC at 760mmHg

[ Melting Point ]:
218-220ºC

[ Molecular Formula ]:
C₁₆H₁₂O₅

[ Molecular Weight ]:
284.26300

[ Flash Point ]:
207.5ºC

[ Exact Mass ]:
284.06800

[ PSA ]:
79.90000

[ LogP ]:
2.87980

[ Vapour Pressure ]:
2.54E-12mmHg at 25°C

[ Index of Refraction ]:
1.668

[ Storage condition ]:
2-8℃

Safety Information

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%