NLRP3-IN-21

Names

[ CAS No. ]:
2956791-61-8

[ Name ]:
NLRP3-IN-21

Biological Activity

[Description]:

NLRP3-IN-21 (compound L38) is a NLRP3 inflammasome inhibitor with inflammatory properties. NLRP3-IN-21 inhibits NLRP3 inflammasome activation and pyroptosis by suppressing gasdermin D cleavage, ASC oligomerization, and NLRP3 inflammasome assembly[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)
Research Areas >> Inflammation/Immunology

[References]

[1]. Na Li, et al. Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis. J Med Chem. 2023 Oct 12;66(19):13428-13451.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H13Cl2F3N6O2S

[ Molecular Weight ]:
529.32

Related Compounds