Ademetionine

Names

[ Name ]:
Ademetionine

[Synonym ]:
ADEMETHIOINEDISULFATETOSYLATE
adenosylmethionine
[3H]-Ademetionine
SAM-E
EINECS 249-946-8
S-Adenosyl-L-methion
MFCD00871208
methioninyladenylate
Bis([(3S)-3-amino-3-carboxypropyl]{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]methyl}methylsulfonium) 1,4-butanedisulfonate
S-adenosyl-L-[methyl(14)C]methionine
ADEMETIONINE
p-Toluenesulfonate salt
Ademetionin
methyl-S-adenosyl-L-Met
[14C]-Ademetionine
SAM
S-Adenosyl-L-methionine

Biological Activity

[Description]:

Ademetionine is an intermediate metabolite of methionine. Its involvement in methylation assists in cellular growth and repair, maintains the phospho-bilipid layer in cell membranes. It also helps in the maintenance of the action of several hormones and neurotransmitters that affect mood.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

Natural Products >> Others

[References]

[1]. Bressa, G.M., S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl, 1994. 154: p. 7-14.

[2]. Najm, W.I., et al., S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord, 2004. 5: p. 6.

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
247-249ºC

[ Molecular Formula ]:
C₁₅H₂₂N₆O₅S

[ Molecular Weight ]:
398.44

[ PSA ]:
547.02000

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7334000

CHEMICAL NAME :: Adenosine, 5'-((L-3-amino-3-carboxypropyl)methylsulfonio)-5'-deo xy-, hydroxide, inner salt

CAS REGISTRY NUMBER :: 29908-03-0

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H22-N6-O5-S

MOLECULAR WEIGHT :: 398.49

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ IZ D- BT5OTJ CQ DQ E1S1&2YZVQ &Q &39/49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 9 umol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 3,349,1982

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
49-23-34

[ Safety Phrases ]:
53-23-36/37/39-45

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%