TAPS (buffer)

Names

[ Name ]:
TAPS (buffer)

[Synonym ]:
1-Propanesulfonic acid, 3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]-
[(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]-1-propanesulfonic acid
3-((1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)propane-1-sulfonic acid
N-Tris(Hydroxymethy)methyl-3-aminopropanesulfonic acid
T3A
3-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}propane-1-sulfonic acid
N-Tris(hydroxymethyl)methyl-3-aminopropanesulfonic Acid [Good's buffer component
EINECS 249-954-1
N-[Tris（hydroxymethyl）metyl]-3-aminopropanesulfonic acid
3-(TRIS(HYDROXYMETHYL)METHYLAMINO)-1-PROPANESULFONIC ACID
3-{[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]amino}-1-propanesulfonic acid
MFCD00007538
TAPS
3-[N-Tris-(hydroxymethyl)methylamino]propanesulphonic (TAPS)
N-Tris(hydroxymethyl)methyl-3-aminopropanesulfonic acid

Biological Activity

[Description]:

TAPS is a biological buffer, remain lysozyme native structure intact and prevents thermal denaturation against high temperatures. TAPS exhibits pKa value of 8.1, while the half-maximum values of connexin channel activity is 8.5 (pH)[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Pannuru P, et al. The effects of biological buffers TRIS, TAPS, TES on the stability of lysozyme. Int J Biol Macromol. 2018 Jun;112:720-727.

[2]. Bevans CG, et al. Regulation of connexin channels by pH. Direct action of the protonated form of taurine and other aminosulfonates. J Biol Chem. 1999 Feb 5;274(6):3711-9.Bevans CG, et al. Regulation of connexin channels by pH. Direct action of the protonated form of taurine and other aminosulfonates. J Biol Chem. 1999 Feb 5;274(6):3711-9.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Melting Point ]:
230-235 °C (dec.)

[ Molecular Formula ]:
C₇H₁₇NO₆S

[ Molecular Weight ]:
243.278

[ Flash Point ]:
110 °C

[ Exact Mass ]:
243.077652

[ PSA ]:
135.47000

[ LogP ]:
-2.40

[ Index of Refraction ]:
1.561

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Incompatible with strong oxidizing agents

[ Water Solubility ]:
Soluble

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29221980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29221980

Articles

The [NiFe]-Hydrogenase of Pyrococcus furiosus Exhibits a New Type of Oxygen Tolerance.

J. Am. Chem. Soc. 137 , 13556-65, (2015)

We report the first direct electrochemical characterization of the impact of oxygen on the hydrogen oxidation activity of an oxygen-tolerant, group 3, soluble [NiFe]-hydrogenase: hydrogenase I from Py...

Towards autotrophic tissue engineering: Photosynthetic gene therapy for regeneration.

Biomaterials 75 , 25-36, (2015)

The use of artificial tissues in regenerative medicine is limited due to hypoxia. As a strategy to overcome this drawback, we have shown that photosynthetic biomaterials can produce and provide oxygen...

Producing glucose 6-phosphate from cellulosic biomass: structural insights into levoglucosan bioconversion.

J. Biol. Chem. 290 , 26638-48, (2015)

The most abundant carbohydrate product of cellulosic biomass pyrolysis is the anhydrosugar levoglucosan (1,6-anhydro-β-d-glucopyranose), which can be converted to glucose 6-phosphate by levoglucosan k...