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PI3Kα-IN-11

Names

[ CAS No. ]:
300803-79-6

[ Name ]:
PI3Kα-IN-11

[Synonym ]:
N-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide
N-Benzyl-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxamide
3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-2-oxo-N-(phenylmethyl)-
4-Hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid benzylamide

Biological Activity

[Description]:

PI3Kα-IN-11 is a potent PI3Kα inhibitor with anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

PI3Kα


[References]

[1]. Sabbah DA, et al.N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα). Bioorg Med Chem. 2012 Dec 15;20(24):7175-83.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
622.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H14N2O3

[ Molecular Weight ]:
294.30

[ Flash Point ]:
330.2±31.5 °C

[ Exact Mass ]:
294.100433

[ LogP ]:
1.04

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.667

Related Compounds