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GSA-10

Names

[ CAS No. ]:
300833-95-8

[ Name ]:
GSA-10

[Synonym ]:
Propyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl)carbonyl]amino}benzoate
Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester
propyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}benzoate
GSA 10
4-[[(1-Hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester

Biological Activity

[Description]:

GSA-10 is a potent agonist of Smoothened (Smo) receptor with an EC50 of 1.2 μM. GSA-10 is a novel quinolinecarboxamide derivative. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 mediates Hedgehog (Hh) signaling which may have researching interests in regenerative medicine for cancer disease[1][2].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Smo
Research Areas >> Cancer

[Target]

Smoothened receptor[1]


[References]

[1]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016;121:747-757.

[2]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened [published correction appears in Mol Pharmacol. 2013 Aug;84(2):303]. Mol Pharmacol. 2013;83(5):1020-1029.

Chemical & Physical Properties

[ Density]:
1.240±0.06 g/cm3

[ Boiling Point ]:
620.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H30N2O5

[ Molecular Weight ]:
450.527

[ Flash Point ]:
328.9±31.5 °C

[ Exact Mass ]:
450.215485

[ PSA ]:
97.63000

[ LogP ]:
5.79

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.610

[ Water Solubility ]:
Insuluble (4.1E-4 g/L) (25 ºC)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Related Compounds