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IQP-0528

Names

[ CAS No. ]:
301297-45-0

[ Name ]:
IQP-0528

[Synonym ]:
1-(cyclopropylmethyl)-6-(3,5-dimethylbenzoyl)-5-(propan-2-yl)pyrimidine-2,4(1h,3h)-dione
2,4(1H,3H)-Pyrimidinedione,1-(cyclopropylmethyl)-6-(3,5-dimethylbenzoyl)-5-isopropyl
UNII-1Y42TZL33O
IQP-528
IQP-0528

Biological Activity

[Description]:

IQP-0528 is a highly potent nonnucleoside reverse transcriptase inhibitor (NNRTI). IQP-0528 shows nanomolar activity against both HIV-1 and HIV-2, with an HIV-1 EC50 of 0.2 nM and an HIV-2 EC50 of 100 nM[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[References]

[1]. Su JT, et al. A Dose Ranging Pharmacokinetic Evaluation of IQP-0528 Released from Intravaginal Rings in Non-Human Primates. Pharm Res. 2017;34(10):2163-2171.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H24N2O3

[ Molecular Weight ]:
340.42

[ Exact Mass ]:
340.17900

[ PSA ]:
72.19000

[ LogP ]:
3.33010

Related Compounds