Malformin A

Names

[ Name ]:
Malformin A

[Synonym ]:
Malformins
MALFORMIN A
Cyclic(D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-isoleucyl)cyclic(1-2)-disulfide
cyclo-D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-isoleucyl
AmbotzLS-1149
Malformin A1
4-(butan-2-yl)-7-(2-methylpropyl)-10-(propan-2-yl)-15,16-dithia-2,5,8,11,19-pentaazabicyclo[11.4.2]nonadecane-3,6,9,12,18-pentone

Biological Activity

[Description]:

Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Sun-Young Park, et al. Malformin A1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway. Int J Oncol. 2017 Sep;51(3):959-966.

Chemical & Physical Properties

[ Density]:
1.123 g/cm3

[ Boiling Point ]:
921ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₃₉N₅O₅S₂

[ Molecular Weight ]:
529.71600

[ Flash Point ]:
510.8ºC

[ Exact Mass ]:
529.23900

[ PSA ]:
196.10000

[ LogP ]:
2.21120

[ Index of Refraction ]:
1.497

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON7050000

CHEMICAL NAME :: Malformin A

CAS REGISTRY NUMBER :: 3022-92-2

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H39-N5-O5-S2

MOLECULAR WEIGHT :: 529.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3100 ug/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 39,1325,1975

Safety Information

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
23/24/25

[ Safety Phrases ]:
36/37/39-45