Depramine

Names

[ CAS No. ]:
303-54-8

[ Name ]:
Depramine

[Synonym ]:
(3-dibenzo[b,f]azepin-5-yl-propyl)-dimethyl-amine
Depramine
Depramina [INN-Spanish]
5-(3-(Dimethylamino)propyl)-5H-dibenz(b,f)azepine
10,11-Dehydroimipramine
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl)
Depraminum [INN-Latin]
5-(8-Dimethylaminopropyl)-iminostilben
Balipramine
5-(3'-Dimethyl-amino-propyl)-5H-dibenz<b,f>azepin

Biological Activity

[Description]:

Depramine (GP 31406) is a tricyclic antidepressant with pharmacologically activity. Depramine inhibits acetylcholinesterase，Mg2+-ATPase，and Na+/K+ ATPase activity[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

Acetylcholinesterase (AChE), Mg2+-ATPase, Na+/K+ ATPase[1]

[References]

[1]. Caratsch CG, et al. Tricyclic antidepressants: action on synaptosomal acetylcholinesterase and ATPase in the brain of guinea pigs and subcellular distribution. Neuropharmacology. 1973 Jun;12(6):563-75.

Chemical & Physical Properties

[ Density]:
1.06g/cm3

[ Boiling Point ]:
413.9ºC at 760mmHg

[ Molecular Formula ]:
C₁₉H₂₂N₂

[ Molecular Weight ]:
278.39

[ Flash Point ]:
185.9ºC

[ Exact Mass ]:
278.17800

[ PSA ]:
6.48000

[ LogP ]:
4.32520

[ Index of Refraction ]:
1.589

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HO1480000

CHEMICAL NAME :: 5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-

CAS REGISTRY NUMBER :: 303-54-8

BEILSTEIN REFERENCE NO. :: 1319717

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H22-N2

MOLECULAR WEIGHT :: 278.43

WISWESSER LINE NOTATION :: T C676 BNJ B3N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%