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MitoBloCK-6

Names

[ CAS No. ]:
303215-67-0

[ Name ]:
MitoBloCK-6

[Synonym ]:
2-{(E)-[(4-Anilinophenyl)imino]methyl}-4,6-dichlorophenol
2,4-Dichloro-6-[(4-phenylamino-phenylimino)-methyl]-phenol
MFCD00557142
Phenol, 2,4-dichloro-6-[(E)-[[4-(phenylamino)phenyl]imino]methyl]-

Biological Activity

[Description]:

MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC50=1.4 μM). MitoBloCK-6 can induce apoptosis via cytochrome c release in hESCs[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Metabolic Disease

[Target]

IC50: 900 nM (Erv1) 700 nM (ALR) 1.4 μM (Erv2)[1]


[References]

[1]. Dabir DV, et, al. A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell. 2013 Apr 15;25(1):81-92.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
535.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H14Cl2N2O

[ Molecular Weight ]:
357.233

[ Flash Point ]:
277.4±30.1 °C

[ Exact Mass ]:
356.048309

[ LogP ]:
6.34

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.627

Related Compounds