BET-IN-7

Names

[ CAS No. ]:
303985-05-9

[ Name ]:
BET-IN-7

Biological Activity

[Description]:

BET-IN-7 (Compound 1) is a potent inhibitor of BET with a Ki and Kd of 12.27 and 89.3 μM, respectively. BET-IN-7 has the potential for the research of sepsis[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[References]

[1]. Chen X, et al. Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis. Eur J Med Chem. 2022 May 8;238:114423

Chemical & Physical Properties

[ Molecular Formula ]:
C18H12ClN3OS

[ Molecular Weight ]:
353.83

Related Compounds