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α-Methyl-5-hydroxytryptamine maleate

Names

[ CAS No. ]:
304-52-9

[ Name ]:
α-Methyl-5-hydroxytryptamine maleate

[Synonym ]:
MFCD00082468
4a-methyl-5-hydroxytryptamine
a-Methyl-5-hydroxytryptaminemaleate

Biological Activity

[Description]:

α-Methylserotonin is a potent and selective agonist of 5-HT2 receptor.α-Methylserotonin is an analogue of serotonin formed in vivo from α-methyltryptophan.α-Methylserotonin mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis[1][2][3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Dobbins DE. Receptor mechanisms of serotonin-induced prenodal lymphatic constriction in the canine forelimb. Am J Physiol. 1998 Feb;274(2):H650-4.

[2]. Brumley MR, et al. The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. Behav Neurosci. 2005 Jun;119(3):821-33.

[3]. Edwards E, et al. (+/-)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane(DOI) and alpha-methyl-5-HT: 5-HT2 receptor agonistic action on phosphatidylinositol metabolism in the rat fronto-cingulate and entorhinal cortex. Neuropharmacology. 1992 Jul;31(7):615-21.

Chemical & Physical Properties

[ Boiling Point ]:
411.7ºC at 760 mmHg

[ Molecular Formula ]:
C15H18N2O5

[ Molecular Weight ]:
306.31400

[ Flash Point ]:
202.8ºC

[ Exact Mass ]:
306.12200

[ PSA ]:
136.64000

[ LogP ]:
2.17530

Safety Information

[ Safety Phrases ]:
22-24/25

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds