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Iproniazid (phosphate)

Names

[ CAS No. ]:
305-33-9

[ Name ]:
Iproniazid (phosphate)

[Synonym ]:
4-pyridinecarboxylic acid
iproniaziddihydrogenphosphate
IPRONIAZID PHOSPHATE SALT
N'-Isopropylisonicotinohydrazide phosphate
1-Isonicotinyl-2-isopropylhydrazine Phosphate
Iproniazidphosphat
phosphate (1:1)
ISONICOTINIC ACID 2-ISOPROPYLHYDRAZIDE PHOSPHATE
IPRONIAZID PHOSP
marsilidphosphate
2-(1-methylethyl)hydrazide
EINECS 206-164-1
iproniazidephosphate
Iproniazid (phosphate)

Biological Activity

[Description]:

Iproniazid is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Neurological Disease

[References]

[1]. Robert A,et al. Drug discovery. Humana Press. pp. 143–154.

[2]. Fagervall I, et al. Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors. Biochemical pharmacology 35 (8): 1381–1387


[Related Small Molecules]

Phenelzine (sulfate) | trans-2-Phenylcyclopropylamine hemisulfate salt | Clorgyline hydrochloride | Rosmarinic acid | pargyline hydrochloride | GSK-LSD1 Dihydrochloride | Rasagiline mesylate | Mofegiline hydrochloride | Paeonol | Safinamide | TVP1022 | Minaprine | Nialamide | Desmethoxyyangonin | Eprobemide

Chemical & Physical Properties

[ Density]:
1.084g/cm3

[ Boiling Point ]:
265.9ºC at 760mmHg

[ Melting Point ]:
181ºC

[ Molecular Formula ]:
C9H16N3O5P

[ Molecular Weight ]:
277.21400

[ Flash Point ]:
114.6ºC

[ Exact Mass ]:
277.08300

[ PSA ]:
141.59000

[ LogP ]:
0.57760

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NS1950000
CHEMICAL NAME :
Isonicotinic acid, 2-isopropylhydrazide, phosphate
CAS REGISTRY NUMBER :
305-33-9
LAST UPDATED :
199803
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C9-H13-N3-O.H3-O4-P
MOLECULAR WEIGHT :
277.25
WISWESSER LINE NOTATION :
T6NJ DVMMY1&1 &QPQQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
442 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
730 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - parasympatholytic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
130 mg/kg
SEX/DURATION :
female 10-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
640 mg/kg
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 9,287,1982

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
23/24/25

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
UN 3249

[ RTECS ]:
NS1950000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds