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Mca-Ala-Pro-Lys(Dnp)-OH

Names

[ CAS No. ]:
305336-82-7

[ Name ]:
Mca-Ala-Pro-Lys(Dnp)-OH

[Synonym ]:
N-(4-Methyl-2-oxo-2H-chromen-7-yl)-L-alanyl-L-prolyl-N-(2,4-dinitrophenyl)-L-lysine
L-Lysine, N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alanyl-L-prolyl-N-(2,4-dinitrophenyl)-

Biological Activity

[Description]:

Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

The activity of ACE2 enzyme detected by: the fluorescent peptide substrate Mca-AlaPro-Lys (Dnp)-OH is hydrolyzed by ACE2 and its product is detected by the active fluorescence resonance energy transfer method[3].

[References]

[1]. Liu J, Ji H, et al. Sex differences in renal angiotensin converting enzyme 2 (ACE2) activity are 17β-oestradiol-dependent and sex chromosome-independent. Biol Sex Differ. 2010;1(1):6. Published 2010 Nov 5.

[2]. Liang Y, et al. Urinary angiotensin converting enzyme 2 increases in patients with type 2 diabetic mellitus. Kidney Blood Press Res. 2015;40(2):101-110.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
989.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H34N6O10

[ Molecular Weight ]:
638.625

[ Flash Point ]:
551.9±34.3 °C

[ Exact Mass ]:
638.233643

[ LogP ]:
3.94

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.658

Related Compounds