N'-benzylpivalohydrazide

Names

[ CAS No. ]:
306-19-4

[ Name ]:
N'-benzylpivalohydrazide

[Synonym ]:
Tersavide
Pivazid
N'-benzyl-2,2-dimethyl-propanehydrazide
N'-benzylpivalohydrazide
Betamezide
N-Benzyl pivalhydrazide
Pivalylbenzhydrazine
1-Trimethylacetyl-2-benzyl-hydrazin
Tersavid
PIVHYDRAZINE
Pivalyl benzylhydrazine
Pivaloylbenzylhydrazine
Betamezid

Biological Activity

[Description]:

Pivalylbenzhydrazine (Pivhydrazine) is a potent monoamine oxidase (MAO) inhibitor. Pivalylbenzhydrazine decreases cartilage growth in normal rats. Pivalylbenzhydrazine can be used in research of depression[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[In Vivo]

Pivalylbenzhydrazine (Pivhydrazine; 5 mg/kg; i.p.; daily, for 5 d; immature female rats) inhibits the growth of the epiphysial cartilage[1]. Animal Model: Immature female rats (40 g, 3-4 weeks age)[1] Dosage: 5 mg/kg Administration: Intraperitoneal injection; daily, for 5 days Result: Inhibited the growth of the epiphysial cartilage

Chemical & Physical Properties

[ Density]:
1.015g/cm3

[ Boiling Point ]:
296.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₈N₂O

[ Molecular Weight ]:
206.28400

[ Flash Point ]:
105.6ºC

[ Exact Mass ]:
206.14200

[ PSA ]:
41.13000

[ LogP ]:
2.63530

[ Index of Refraction ]:
1.517

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TO7874000

CHEMICAL NAME :: Pivalic acid, 2-benzylhydrazide

CAS REGISTRY NUMBER :: 306-19-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H18-N2-O

MOLECULAR WEIGHT :: 206.32

WISWESSER LINE NOTATION :: 1X1&1&VMM1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 10 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 5,343,1968

Safety Information

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2928000090

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%