<Suppliers Price>

WAY 170523

Names

[ CAS No. ]:
307002-73-9

[ Name ]:
WAY 170523

Biological Activity

[Description]:

WAY-170523 is a potent and selective MMP-13 (matrix metalloproteinase-13) inhibitor, with an IC50 of 17 nM. WAY-170523 can directly attenuate ERK1/2 phosphorylation. WAY-170523 inhibits the invasion of PC-3 cells, can be used for prostate cancer research[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

MMP13:17 nM (IC50)

MMP-1:10 μM (IC50)

MMP-9:945 nM (IC50)


[In Vitro]

WAY-170523 has an IC50 of 17 nM for MMP-13 and shows > 5800-, 56-, and > 500-fold selectivity against MMP-I, MMP-9, and TACE, respectively.

[References]

[1]. James M. Chen, et al. Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design. J. Am. Chem. Soc. 2000, 122, 40, 9648-9654.

[2]. Mervi Toriseva, et al. Phenotypic screening using AMIDA identifies different drug responses in breast and prostate cancer cell lines in an organotypic cell culture model. Cancer Res (2018) 78 (13_Supplement): 1158.

Chemical & Physical Properties

[ Density]:
1.352g/cm3

[ Molecular Formula ]:
C33H31N3O7S

[ Molecular Weight ]:
613.68

[ Exact Mass ]:
613.18800

[ PSA ]:
146.56000

[ LogP ]:
7.23550

[ Index of Refraction ]:
1.656

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds