Methyl 5-hydroxypyridine-2-carboxylate

Names

[ Name ]:
Methyl 5-hydroxypyridine-2-carboxylate

[Synonym ]:
5-Hydroxy-2-(methoxycarbonyl)pyridine
5-Hydroxypyridine-2-carboxylic acid methyl ester
5-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
Methyl 5-hydroxypicolinate
methyl 5-hydroxypyridin-2-carboxylate
Methyl3-hydroxypicolinate
2-Pyridinecarboxylic acid, 5-hydroxy-, methyl ester
Methyl 5-hydroxy-2-pyridinecarboxylate
5-Hydroxy-2-pyridinecarboxylic Acid Methyl Ester
Methyl 5-hydroxypyridine-2-carboxylate
5-Hydroxy-pyridin-2-carbonsaeure-methylester

Biological Activity

[Description]:

Methyl 5-hydroxypyridine-2-carboxylate is a phenolic acid that can found in the stems of Mahonia fortune. Methyl 5-hydroxypyridine-2-carboxylate exhibits NO inhibitory effects in vitro[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Methyl 5-hydroxypyridine-2-carboxylate (compound 2) inhibits NO in LPS-stimulated RAW264.7 and BV2 cells, with IC50s of 115.67 and 118.80 μM, respectively[1]. Methyl 5-hydroxypyridine-2-carboxylate (6.25-200 μM) does not exhibit any cytotoxic effect[1].

[References]

[1]. Liu L, et, al. Simultaneous characterisation of multiple Mahonia fortunei bioactive compounds in rat plasma by UPLC-MS/MS for application in pharmacokinetic studies and anti-inflammatory activity in vitro. J Pharm Biomed Anal. 2020 Feb 5;179:113013.

[2]. Liu L, et, al. Simultaneous characterisation of multiple Mahonia fortunei bioactive compounds in rat plasma by UPLC-MS/MS for application in pharmacokinetic studies and anti-inflammatory activity in vitro. J Pharm Biomed Anal. 2020 Feb 5;179:113013.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
374.2±22.0 °C at 760 mmHg

[ Melting Point ]:
193.5-195.5℃

[ Molecular Formula ]:
C₇H₇NO₃

[ Molecular Weight ]:
153.135

[ Flash Point ]:
180.1±22.3 °C

[ Exact Mass ]:
153.042587

[ PSA ]:
59.42000

[ LogP ]:
0.82

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.552

MSDS

Click to get detail MSDS

Safety Information

[ Risk Phrases ]:
20/21/22

[ Safety Phrases ]:
24/25-36/37

[ HS Code ]:
2933399090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%