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5'-Hydroxy-staurosporine

Names

[ CAS No. ]:
308847-74-7

[ Name ]:
5'-Hydroxy-staurosporine

Biological Activity

[Description]:

5'-Hydroxy-staurosporine is an indolocarbazole alkaloid that can be isolated from marine Micromonospora sp. (strain L-31-CLCO-002). 5'-Hydroxy-staurosporine can be used in tumor related research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

5'-Hydroxy-staurosporine 抑制 P388D1、A549、HT-29 和 SK-MEL-28 细胞活性，IC50 值分别为 0.02 µM、0.002 µM、0.004 µM 和 0.002 µM[1]。

[References]

[1]. Hernández LM, et al. 4'-N-methyl-5'-hydroxystaurosporine and 5'-hydroxystaurosporine, new indolocarbazole alkaloids from a marine Micromonospora sp. strain. J Antibiot (Tokyo). 2000 Sep;53(9):895-902.  

Chemical & Physical Properties

[ Molecular Formula ]:
C28H26N4O4

[ Molecular Weight ]:
482.53

Related Compounds