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IMR-1

Names

[ CAS No. ]:
310456-65-6

[ Name ]:
IMR-1

[Synonym ]:
Ethyl {2-methoxy-4-[(E)-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetate
Acetic acid, 2-[2-methoxy-4-[(E)-(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-, ethyl ester
IMR-1

Biological Activity

[Description]:

IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.target: NotchIC 50: 6 μmol/LIn vitro: IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth .A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO). In vivo : The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish.

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Notch
Research Areas >> Cancer

[References]

[1]. Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.


[Related Small Molecules]

RO4929097 | Crenigacestat(LY3039478) | YO-01027 | LY-411575 | Tangeretin | FLI-06 | Avagacestat | BMS-983970 | Semagacestat(LY450139) | Z-Ile-Leu-aldehyde | IMR-1A | Psoralidin | tCFA15

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C15H15NO5S2

[ Molecular Weight ]:
353.413

[ Exact Mass ]:
353.039154

[ LogP ]:
1.38

[ Appearance of Characters ]:
yellow solid

[ Index of Refraction ]:
1.641

[ Storage condition ]:
-20℃

Related Compounds