ELN484228

Names

[ CAS No. ]:
312-63-0

[ Name ]:
ELN484228

[Synonym ]:
4-Fluor-N-phenylbenzolsulfonamid
4'-fluorobenzenesulfonanilide
ELN484228

Biological Activity

[Description]:

ELN484228 is a blocker of α-synuclein which is a key protein in Parkinson’s disease.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

α-synuclein[1]

[References]

[1]. Tóth G, et al. Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. PLoS One. 2014 Feb 14;9(2):e87133.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.374g/cm3

[ Boiling Point ]:
379.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₀FNO₂S

[ Molecular Weight ]:
251.27700

[ Flash Point ]:
183ºC

[ Exact Mass ]:
251.04200

[ PSA ]:
54.55000

[ LogP ]:
3.78030

[ Index of Refraction ]:
1.618

[ Storage condition ]:
2-8℃

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%