Bromo-PEG3-bromide

Names

[ Name ]:
Bromo-PEG3-bromide

[Synonym ]:
1,11-ibromo-3,6,9-trioxaundecane
1,11-dibromo-3,6,9-trioxaundecane
3,6,9-trioxa-1,11-dibromoundecane
3,6,9-trioxaundecane-1,11-dibromide

Biological Activity

[Description]:

Bromo-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.57 g/cm3at 25°C (lit.)

[ Boiling Point ]:
146 °C at 0.06 Torr (lit.)

[ Molecular Formula ]:
C₈H₁₆Br₂O₃

[ Molecular Weight ]:
320.01900

[ Exact Mass ]:
317.94700

[ PSA ]:
27.69000

[ LogP ]:
1.82600

Safety Information

[ Hazard Codes ]:
Xi

Bromo-PEG3-bromide

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds