Virginiamycin B

Names

[ Name ]:
Virginiamycin B

[Synonym ]:
Antibiotic PA 114B
Mikamycin B
Ostreogrycin B
PA 114B
Pristinamycin IA
Antibiotic PA 114 B1
Vernamycin BA
Mikamycin IA
Streptogramin B

Biological Activity

[Description]:

Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family, a substrate for the P-glycoprotein.In vitro: Pristinamycin IA specifically inhibits the efflux of the P-glycoprotein substrate [3H]vinblastine, thus increasing the cellular accumulation of the drug. Pristinamycin IA also reduces by 70% the basolateral to apical secretion of [3H]vinblastine across Caco-2 cell monolayers. The cellular accumulation of [14C]pristinamycin IA is very low and is increased by P-glycoprotein inhibitors (verapamil, chlorpromazine and reserpine). The basolateral to apical transport of [14C]pristinamycin IA is 100-fold higher than apical to basolateral passage. [1]

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

Peptides

[References]

[1]. Phung-Ba V et al. Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells. Eur J Pharmacol. 1995 Jan 16;288(2):187-92.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Boiling Point ]:
1202.1ºC at 760mmHg

[ Molecular Formula ]:
C₄₅H₅₄N₈O₁₀

[ Molecular Weight ]:
866.95800

[ Flash Point ]:
680.8ºC

[ Exact Mass ]:
866.39600

[ PSA ]:
227.96000

[ LogP ]:
2.13220

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZA4870000

CHEMICAL NAME :: Virginiamycin S1, 4-(4(dimethylamino)-N-methyl-L-phenylalanine)-

CAS REGISTRY NUMBER :: 3131-03-1

BEILSTEIN REFERENCE NO. :: 0078387

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C45-H54-N8-O10

MOLECULAR WEIGHT :: 867.07

WISWESSER LINE NOTATION :: T F5-19-6 ANV DNV JNV MMV QOV TMV A&VTJ C1R DN1&1& D1 L2 P1 SR& OMV- BT6NJ CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,750,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,367,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,750,1967

Safety Information

[ RIDADR ]:
UN 3172

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)