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O-Nornuciferine

Names

[ CAS No. ]:
3153-55-7

[ Name ]:
O-Nornuciferine

[Synonym ]:
4H-Dibenzo[de,g]quinolin-2-ol, 5,6,6a,7-tetrahydro-1-methoxy-6-methyl-, (6aR)-
(6aR)-1-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol

Biological Activity

[Description]:

O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vitro]

O-Nornuciferine has an IC50 of 7.91 μM in vitro hERG blockages measured in HEK293 cells[1]. O-Nornuciferine (100 μM) has 47% hERG channel inhibition in Xenopus oocytes by lotus alkaloids[1].

[References]

[1]. Ulrike Grienke, et al. Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids From Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements. J Agric Food Chem. 2015 Jun 17;63(23):5634-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
451.4±45.0 °C at 760 mmHg

[ Melting Point ]:
195-197℃ (ethyl acetate )

[ Molecular Formula ]:
C18H19NO2

[ Molecular Weight ]:
281.349

[ Flash Point ]:
226.8±28.7 °C

[ Exact Mass ]:
281.141571

[ PSA ]:
32.70000

[ LogP ]:
3.36

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.634

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds