SIB 1757

Names

[ CAS No. ]:
31993-01-8

[ Name ]:
SIB 1757

[Synonym ]:
2-Benzoazo-6-methyl-3-hydroxypyridin
6-methyl-2-phenylazo-pyridin-3-ol

Biological Activity

[Description]:

SIB-1757 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC50 of 0.4 μM[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

human mGluR5:0.4 μM (IC50)

[References]

[1]. Varney MA, et al. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J Pharmacol Exp Ther. 1999 Jul;290(1):170-81.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₁N₃O

[ Molecular Weight ]:
213.24

[ Exact Mass ]:
213.09000

[ PSA ]:
57.84000

[ LogP ]:
3.51100

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%