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Lixisenatide

Names

[ CAS No. ]:
320367-13-3

[ Name ]:
Lixisenatide

[Synonym ]:
ZP 10
AVE 0010
ZP10A peptide
lixisenatide
des-38-proline-exendine-4 (Heloderma suspectum)-(1-39)- peptidylpenta-L-lysyl-L-lysinamide
AVE0010
Lyxumia
UNII-74O62BB01U

Biological Activity

[Description]:

Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used in the treatment of type 2 diabetes mellitus (T2DM). Sequence: His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-NH2.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor
Research Areas >> Metabolic Disease
Peptides

[Target]

GLP-1 receptor[1][2].


[References]

[1]. Ahrén B et al. Postprandial Glucagon Reductions Correlate to Reductions in Postprandial Glucose and Glycated Hemoglobin with Lixisenatide Treatment in Type 2 Diabetes Mellitus: A Post Hoc Analysis. Diabetes Ther. 2016 Jun 18

[2]. Lorenz M, et al. Effects of lixisenatide once daily on gastric emptying in type 2 diabetes--relationship to postprandial glycemia. Regul Pept. 2013 Aug 10;185:1-8.


[Related Small Molecules]

Exenatide acetate salt | Adomeglivant | Exendin Fragment 9-39 | MK 0893 | GLP-1(7-36) Acetate | GLP-1 (7-37) | LGD-6972 | Taspoglutide | GRA Ex-25 | GLP-1 receptor agonist 1 | GLP-1 receptor agonist-1 | GLP-2 (human)

Chemical & Physical Properties

[ Molecular Formula ]:
C215H347N61O65S

[ Molecular Weight ]:
4858.49000

[ Exact Mass ]:
4855.54000

[ PSA ]:
2085.46000

[ LogP ]:
2.13170

[ Storage condition ]:
-20°C

Related Compounds