1-Fluoronaphthalene

Names

[ CAS No. ]:
321-38-0

[ Name ]:
1-Fluoronaphthalene

[Synonym ]:
1-FLUORONAPTHALENE
α-Fluoronaphthalene
1-fluoromaphthalene
1-fluoro-naphthalen
Naphthalene, 1-fluoro-
EINECS 206-287-0
1-Fluornaphthalen
4-fluoro-l-naphthalene
I-Fluoronaphthalene
1-Flouronaphthalene
I-Fluornaphthalin
L66J BF
MFCD00003873
1-Fluoronaphthalene
1-Fluornaftalen
1-FLUORO NAPHTHALENE

Biological Activity

[Description]:

1-Fluoronaphthalene is an organofluorine compound derived from naphthalene derivatives and fluorinated aromatics. 1-Fluoronaphthalene can be used to synthesize LY248686, a potent inhibitor of serotonin and noradrenaline uptake[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

1-Fluoronaphthalene (3 mg, 24 h) can be oxidized by C.elegans ATCC 36112 to form trans-3,4-dihydroxy-3,4-dihydro-1-fluoronaphthalene and trans-5,6-dihydroxy-5,6-dihydro-1-fluoronaphthalene and to form 1-fluoro-8-hydroxy-5-tetralone, 5-hydroxy-1-fluoronaphthalene and 4-hydroxy-1-fluoronaphthalene as well as glucosides, sulfates and glucuronide conjugates of these phenols[1].

[References]

[1]. C E Cerniglia, et al. Effects of a fluoro substituent on the fungal metabolism of 1-fluoronaphthalene. Appl Environ Microbiol. 1984 Aug;48(2):294-300.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
215.0±0.0 °C at 760 mmHg

[ Melting Point ]:
−13 °C(lit.)

[ Molecular Formula ]:
C₁₀H₇F

[ Molecular Weight ]:
146.161

[ Flash Point ]:
65.6±0.0 °C

[ Exact Mass ]:
146.053177

[ LogP ]:
3.50

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.606

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ7100000

CHEMICAL NAME :: Naphthalene, 1-fluoro-

CAS REGISTRY NUMBER :: 321-38-0

BEILSTEIN REFERENCE NO. :: 1906413

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H7-F

MOLECULAR WEIGHT :: 146.17

WISWESSER LINE NOTATION :: L66J BF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 22,1133,1937 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4416 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S36/37-S24/25-S23-S53

[ RIDADR ]:
UN 2810

[ WGK Germany ]:
3

[ RTECS ]:
QJ7100000

[ HS Code ]:
2903999090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Synthesis of highly oxygenated dinaphthyl ethers via SNAr reactions promoted by Barton's base.

Org. Lett. 5(7) , 1155-8, (2003)

[reaction: see text] Electron-rich dinaphthyl ethers were synthesized by S(N)Ar reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) ...

Effects of a fluoro substituent on the fungal metabolism of 1-fluoronaphthalene.

Appl. Environ. Microbiol. 48(2) , 294-300, (1984)

The metabolism of 1-fluoronaphthalene by Cunninghamella elegans ATCC 36112 was studied. The metabolites were isolated by reverse-phase high-pressure liquid chromatography and characterized by the appl...

A one-pot access to 6-substituted phenanthridines from fluoroarenes and nitriles via 1,2-arynes.

Org. Lett. 4(16) , 2687-90, (2002)

[reaction: see text] A one-pot, t-BuLi-induced synthesis of 6-substituted phenanthridines from fluoroarenes and nitriles via 1,2-arynes is reported. Aryl- and hetaryl nitriles, cyanamides, and trimeth...