Medifoxamine

Names

[ Name ]:
Medifoxamine

[Synonym ]:
Medifoxamine
N,N-Dimethyl-2,2-diphenoxy-ethylamin
Medifoxamina
EINECS 251-011-4
Medifoxamin
2,2-Bisphenoxy-dimethyl-aminoethane
N,N-Dimethyl-2,2-diphenoxyethylamine
2,2-bis phenoxy-N,N-dimethyl ethylamine

Biological Activity

[Description]:

Medifoxamine is a monoamine re-uptake inhibiting antidepressive drug which preferentially inhibits dopamine reuptake[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Saleh S, et al. Ocular hypotensive effects of medifoxamine. Br J Clin Pharmacol. 1992;34(3):269-271.

Chemical & Physical Properties

[ Density]:
1.076g/cm3

[ Boiling Point ]:
380ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₉NO₂

[ Molecular Weight ]:
257.33

[ Flash Point ]:
132.9ºC

[ Exact Mass ]:
257.14200

[ PSA ]:
21.70000

[ LogP ]:
3.03210

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB2825300

CHEMICAL NAME :: Acetaldehyde, (dimethylamino)-, diphenyl acetal

CAS REGISTRY NUMBER :: 32359-34-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H19-N-O2

MOLECULAR WEIGHT :: 257.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - excitement Behavioral - changes in motor activity (specific assay)

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,553,1971

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%