2-HYDROXY-2-ISOPROPYLSUCCINIC ACID

Names

[ Name ]:
2-HYDROXY-2-ISOPROPYLSUCCINIC ACID

[Synonym ]:
2-hydroxy-2-isopropyl-succinic acid
2-HYDROXY-2-ISOPROPYLSUCCINIC ACID
2-Hydroxy-2-isopropyl-bernsteinsaeure
MFCD00075003
2-Hydroxy-2-isopropylbutanedioic acid

Biological Activity

[Description]:

α-Isopropylmalate (α-IPM) is the leucine biosynthetic precursor in Yeast[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

α-Isopropylmalate (500 μM) increases LEU3 protein (Leu3p)-dependent transcription[1]. α-Isopropylmalate (10 mM, 48 h) increases reporter gene expression in preadipocytes (30A5)[2].

Chemical & Physical Properties

[ Density]:
1.342g/cm3

[ Boiling Point ]:
306.4ºC at 760mmHg

[ Melting Point ]:
144-146ºC(lit.)

[ Molecular Formula ]:
C₇H₁₂O₅

[ Molecular Weight ]:
176.16700

[ Flash Point ]:
153.3ºC

[ Exact Mass ]:
176.06800

[ PSA ]:
94.83000

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-37/39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes.

Metabolomics 11 , 1277-1286, (2015)

Biomarkers for the development of type 2 diabetes (T2D) are useful for prediction and intervention of the disease at earlier stages. In this study, we performed a longitudinal study of changes in meta...

Human metabolic responses to chronic environmental polycyclic aromatic hydrocarbon exposure by a metabolomic approach.

J. Proteome Res. 14 , 2583-93, (2015)

The toxicities of polycyclic aromatic hydrocarbons (PAHs) have been extensively explored due to their carcinogenic and mutagenic potency; however, little is known about the metabolic responses to chro...

A potential tool for diagnosis of male infertility: Plasma metabolomics based on GC-MS.

Talanta 147 , 82-9, (2015)

Male infertility has become an important public health problem worldwide. Nowadays the diagnosis of male infertility frequently depends on the results of semen quality or requires more invasive surgic...