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AKTide-2T TFA

Names

[ CAS No. ]:
324029-01-8

[ Name ]:
AKTide-2T TFA

[Synonym ]:
ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA
ARKRERTYSFGHHA
H-ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA-OH
AKT/PKB/Rac-Protein Kinase Substrate
Substrate for AKT/PKB/Rac-protein Kinase

Biological Activity

[Description]:

AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

Akt


[In Vitro]

AKTide-2T mimics the optimal phosphorylation sequence of Akt, and inhibits Akt phosphorylated Hsp27 by addition of 20 μM Akt inhibitory peptide[1].

[References]

[1]. T Obata,et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem. 2000 Nov 17;275(46):36108-15.

[2]. Madhavi J Rane, et al. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem. 2003 Jul 25;278(30):27828-35.

Chemical & Physical Properties

[ Melting Point ]:
153-156ºC

[ Molecular Formula ]:
C74H114N28O20

[ Molecular Weight ]:
1715.87000

[ Exact Mass ]:
1714.88000

[ PSA ]:
808.69000

[ LogP ]:
0.70630

[ Storage condition ]:
-20°C

Related Compounds