(R)-2-AMINO-3-(PROP-2-YN-1-YLTHIO)PROPANOIC ACID

Names

[ Name ]:
(R)-2-AMINO-3-(PROP-2-YN-1-YLTHIO)PROPANOIC ACID

[Synonym ]:
(R)-2-Amino-3-(2-propynylthio)propanoicAcid
(R)-2-Amino-3-(2-propynylthio)propanoic Acid
2-amino-3-prop-2-ynylsulfanyl-propionic acid
S-propargyl cysteine
S-Prop-2-inyl-L-cystein
(R)-2-Amino-3-(prop-2-yn-1-ylthio)propanoic acid
S-2-Propinyl-L-cystein
S-prop-2-ynyl-L-cysteine
S-propargyl-L-cysteine

Biological Activity

[Description]:

S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H2S-releasing compound. S-Propargylcysteine reduces Ca2+ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties[1][2].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT

Signaling Pathways >> JAK/STAT Signaling >> STAT

Signaling Pathways >> Apoptosis >> MDM-2/p53

Research Areas >> Inflammation/Immunology

[References]

[1]. Sidhapuriwala JN, et al. Effects of S-propargyl-cysteine (SPRC) in caerulein-induced acute pancreatitis in mice. PLoS One. 2012;7(3):e32574.

[2]. Wen YD, et al. The Pharmacological Effects of S-Propargyl-Cysteine, a Novel Endogenous H2S-Producing Compound. Handb Exp Pharmacol. 2015;230:325-36.

Chemical & Physical Properties

[ Density]:
1.284g/cm3

[ Boiling Point ]:
294.8ºC at 760 mmHg

[ Melting Point ]:
176-178 °C

[ Molecular Formula ]:
C₆H₉NO₂S

[ Molecular Weight ]:
159.21

[ Flash Point ]:
132.1ºC

[ Exact Mass ]:
159.03500

[ PSA ]:
88.62000

[ LogP ]:
0.46500

[ Index of Refraction ]:
1.57

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2930909090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%