1-OLEOYL-2-HYDROXY-SN-GLYCERO-3[PHOSPHO-L-SERINE](SODIUM SALT)

Names

[ Name ]:
1-OLEOYL-2-HYDROXY-SN-GLYCERO-3[PHOSPHO-L-SERINE](SODIUM SALT)

[Synonym ]:
9-Octadecenoic acid, (2R)-3-[[[(2S)-2-amino-2-carboxyethoxy]hydroxyphosphinyl]oxy]-2-hydroxypropyl ester, sodium salt, (9Z)- (1:1)
Sodium (2S,8R,19Z)-2-amino-5,8-dihydroxy-11-oxo-4,6,10-trioxa-5-phosphaoctacos-19-en-1-oate 5-oxide

Biological Activity

[Description]:

Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product generated following activation of the NADPH oxidase and lyso-PS signaling. Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium through the macrophage G2A functions to enhance existing receptor/ligand systems for resolution of neutrophilic inflammation[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Frasch SC, et, al. NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A. J Biol Chem. 2008 Nov 28;283(48):33736-49.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₄₅NNaO₉P

[ Molecular Weight ]:
545.579

[ Exact Mass ]:
545.272949

Safety Information

[ Hazard Codes ]:
Xi