cis,trans-Germacrone

Names

[ CAS No. ]:
32663-51-7

[ Name ]:
cis,trans-Germacrone

[Synonym ]:
cis,trans-Germacron

Biological Activity

[Description]:

cis,trans-Germacrone is a isomer of Germacrone (HY-N0440). Germacrone exhibits a wide range of antitumor, antioxidant and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters the Akt/MDM2/p53. Germacrone also arrests cell cycle at G1/S phase[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> MDM-2/p53
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[References]

[1]. Zhao Y, et al. Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway. Mol Med Rep. 2021 Jun;23(6):452.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H22O

[ Molecular Weight ]:
218.33500

[ Exact Mass ]:
218.16700

[ PSA ]:
17.07000

[ LogP ]:
4.35850

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds