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Shz 1

Names

[ CAS No. ]:
326886-05-9

[ Name ]:
Shz 1

[Synonym ]:
N'-[(E)-(5-Bromo-2-hydroxyphenyl)methylene]benzenesulfonohydrazide
Benzenesulfonic acid, 2-[(1E)-(5-bromo-2-hydroxyphenyl)methylene]hydrazide
Shz-1

Biological Activity

[Description]:

Shz-1, a small cardiogenic molecule, induces various cardiac-specific genes including sarcomeric tropomyosin in P19CL6 cells. Shz-1 induces Nkx2.5 expression in mouse. Shz-1 activates the axolotl TPM4 promoter-driven ectopic expression in C2C12 cells[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[References]

[1]. Changlong Nan, et al. Expression of sarcomeric tropomyosin in striated muscles in axolotl treated with shz-1, a small cardiogenic molecule. Cardiovasc Toxicol. 2015 Jan;15(1):29-40.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
503.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H11BrN2O3S

[ Molecular Weight ]:
355.207

[ Flash Point ]:
258.5±32.9 °C

[ Exact Mass ]:
353.967377

[ LogP ]:
4.07

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.648

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Related Compounds