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TKIM

Names

[ CAS No. ]:
326921-25-9

[ Name ]:
TKIM

Biological Activity

[Description]:

TKIM is a TREK-1 channel inhibitor with an IC50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Yuqin Ma, et al. Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating. J Med Chem. 2020 Oct 8;63(19):10972-10983.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H14ClN3O2S

[ Molecular Weight ]:
371.84

Related Compounds