NS 19504

Names

[ Name ]:
NS 19504

[Synonym ]:
5-[(4-bromophenyl)methyl]-1,3-thiazol-2-amine
2-amino-5-(4-bromobenzyl)-1,3-thiazole

Biological Activity

[Description]:

NS19504 is a Ca2+-activated K+ channel (BK channel, KCa1.1 channel) activator (EC50=11.0 µM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

EC50: 11.0 µM (BK channel)[1]

[In Vitro]

NS19504 increases BK currents in freshly isolated guinea pig bladder smooth muscle cells and whole-cell. NS19504 increases the whole-cell currents response to 127 %, 194 %, 258 %, 561 % of control at a concentration of 0.32 µM, 1.0 µM, 3.2 µM and 10 µM, respectively[1].

[References]

[1]. Nausch B, et al. NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J Pharmacol Exp Ther. 2014 Sep;350(3):520-30.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₉BrN₂S

[ Molecular Weight ]:
269.16100

[ Exact Mass ]:
267.96700

[ PSA ]:
67.15000

[ LogP ]:
3.65980

NS 19504

Names

Biological Activity

Chemical & Physical Properties

Related Compounds