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tcY-NH2

Names

[ CAS No. ]:
327177-34-4

[ Name ]:
tcY-NH2

[Synonym ]:
TCY-NH2
trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-amide trifluoroacetate salt
trans-Cinnamoyl-YPGKF-NH2

Biological Activity

[Description]:

tcY-NH2 is a selective rat PAR4 antagonist peptide. tcY-NH2 inhibits thrombin- and AY-NH2-induced rat platelet aggregation[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)
Research Areas >> Metabolic Disease

[References]

[1]. Morley D Hollenberg, et al. Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br J Pharmacol. 2004 Oct;143(4):443-54.

[2]. L Ma, et al. Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br J Pharmacol. 2001 Oct;134(4):701-4.

Chemical & Physical Properties

[ Molecular Formula ]:
C42H50F3N7O9

[ Molecular Weight ]:
853.88300

[ Exact Mass ]:
853.36200

[ PSA ]:
263.35000

[ LogP ]:
4.60210

Safety Information

[ Safety Phrases ]:
S22-S24/25

Related Compounds